Adaptive optics (AO) techniques allow to measure and manipulate the wavefront aberrations in real time. This technology was first successfully applied to the manipulation of ocular aberrations, and high resolution retinal images and “supernormal vision” were achieved in vivo for the first time in 1997. Subsequently, adaptive optics were developed rapidly in ophthalmology. This field includes two main directions: high resolution imaging of the retina and the research of ocular aberrations manipulation and its influence on visual function. In 2011, professor D. R. Williams from Rochester University and Professor Austin Roorda from California University made two comprehensive overviews on retinal high-resolution imaging and ocular aberrations manipulation and its influence on visual function, respectively. In 1997, reseachers in Institute of Optics and Electronics took the lead in developing of adaptive optics technology in China. This article firstly introduces the principle of ocular adaptive optical system briefly, and then reports the main research progress of Institute of Optics and Electronics in this field for the last five years.
Ocular aberrations manipulation with adaptive optics and its application (From OEE, Vol.45, No.3)
First published at:May 08, 2018
 Liang J Z, Williams D R. Aberrations and retinal image quality of the normal human eye[J]. Journal of the Optical Society of America A, 1997, 14(11): 2873–2883.
 Williams D R. Imaging single cells in the living retina[J]. Vision Research, 2011, 51(13): 1379-1396, doi: 10.1016/j.visres.2011. 05.002.
 Roorda A. Adaptive optics for studying visual function: A com-prehensive review[J]. Journal of Vision, 2011, 11(5): 6.
 Rossi E A, Weiser P, Tarrant J, et al. Visual performance in emmetropia and low myopia after correction of high-order aberrations[J]. Journal of Vision, 2007, 7(8): 14.
 Chen L, Artal P, Gutierrez D, et al. Neural compensation for the best aberration correction[J]. Journal of Vision, 2007, 7(10): 9.
 Elliott S L, Choi S S, Doble N, et al. Role of high-order aberrations in senescent changes in spatial vision[J]. Journal of Vision, 2009, 9(2): 24.
 Dai Y, Zhao L N, Xiao F, et al. Adaptive optics vision simulation and perceptual learning system based on a 35-element bimorph deformable mirror[J]. Applied Optics, 2015, 54(5): 979–985.
 Zhou J W, Zhang Y D, Dai Y, et al. The eye limits the brain’s learning potential[J]. Scientific Reports, 2012, 2: 364, doi: 10.1038/srep00364.
 Liao M, Zhao H X, Liu L Q, et al. Training to improve contrast sensitivity in amblyopia: correction of high-order aberrations[J]. Scientific Reports, 2016, 6: 35702, doi: 10.1038/srep35702.
 Liang B. Effects of adaptive optics correction of ocular aberrations on binocular summation[D]. Chengdu: Institute of Optics and Electronics, Chinese Academy of Sciences, 2013. 梁波. 自适应光学像差矫正对双眼叠加作用的影响研究[D]. 成都: 中国科学院光电技术研究所, 2013.
 Kang J, Xiao F, Zhao J L, et al. Effects of higher-order aberration correction on stereopsis at different viewing durations[J]. Journal of Biomedical Optics, 2015, 20(7): 075005.
 Kang J, Dai Y, Zhang Y D. Temporal integration property of stereopsis after higher-order aberration correction[J]. Biomedical Optics Express, 2015, 6(11): 4472–4482.
 Kang J. Effect of ocular higher-order aberration correction on stereopsis and binocular accommodation[D]. Chengdu: Institute of Optics and Electronics, Chinese Academy of Sciences, 2016. 康健. 人眼高阶像差校正对立体视觉和双眼调节的影响研究[D]. 成都: 中国科学院光电技术研究所, 2016.
 IJspeert J K, de Waard P W T, van den Berg T J T P, et al. The intraocular straylight function in 129 healthy volunteers; De-pendence on angle, age and pigmentation[J]. Vision Research, 1990, 30(5): 699–707.
 Artal P, Benito A, Pérez G M, et al. An objective scatter index based on double-pass retinal images of a point source to classify cataracts[J]. PLoS One, 2011, 6(2): e16823.
 Güell J L, Pujol J, Arjona M, et al. Optical quality analysis system; instrument for objective clinical evaluation of ocular optical quality[J]. Journal of Cataract and Refractive Surgery, 2004, 30(7): 1598–1599.
 Benito A, Pérez G M, Mirabet S, et al. Objective optical as-sessment of tear-film quality dynamics in normal and mildly symptomatic dry eyes[J]. Journal of Cataract & Refractive Surgery, 2011, 37(8): 1481–1487.
 Nanavaty M A, Stanford M R, Sharma R, et al. Use of the double-pass technique to quantify ocular scatter in patients with uveitis: A pilot study[J]. Ophthalmologica, 2011, 225(1): 61–66.
 Piñero D P, Ortiz D, Alio J L. Ocular scattering[J]. Optometry and Vision Science: Official Publication of the American Academy of Optometry, 2010, 87(9): E682–E96.
 Artal P, Iglesias I, López-Gil N, et al. Double-pass measure-ments of the retinal-image quality with unequal entrance and exit pupil sizes and the reversibility of the eye’s optical system[J]. Journal of the Optical Society of America A, 1995, 12(10): 2358–2366.
 Zhao J L. Objective assessment of ocular scatter and its influence on visual function[D]. Chengdu: Institute of Optics and Electronics, Chinese Academy of Sciences, 2017. 赵军磊. 人眼散射客观评价及其对视功能影响研究[D]. 成都: 中国科学院光电技术研究所, 2017.
 Zhao J L, Xiao F, Kang J, et al. Quantifying intraocular scatter with near diffraction-limited double-pass point spread function[J]. Biomedical Optics Express, 2016, 7(11): 4595–4604.
 Zhao J L, Xiao F, Zhao H X, et al. Effect of higher-order aberrations and intraocular scatter on contrast sensitivity measured with a single instrument[J]. Biomedical Optics Express, 2017, 8(4): 2138–2147.
 Xiao F, Zhao J L, Zhao H X, et al. Deblurring adaptive optics retinal images using deep convolutional neural networks[J]. Biomedical Optics Express, 2017, 8(12): 5675–5687.
National Natural Science Foundation of China (61205202, 61378064), National High Technology Research and Development Program of China (2015AA020510), National Scientific Instrumentsand Equipment Development Special Foundation of China (2012YQ120080, 2013YQ49085903) and Instrument Developing Project of the Chinese Academy of Sciences (y2010028)
Get Citation: Dai Y, Xiao F, Zhao J L, et al. Ocular aberrations manipulation with adaptive optics and its application[J]. Opto-Electronic Engineering, 2018, 45(3): 170703.
Previous: Recent progress of adaptive beam cleanup of solid-state slab lasers in Institute of Optics and Electronics, Chinese Academy of Sciences (From OEE, Vol.45, No.3)
Opto-Electronic …, 2018