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Zhu J M, Zhu X Q, Zuo Y F, Hu X J, Shi Y et al. Optofluidics: the interaction between light and flowing liquids in integrated devices. Opto-Electron Adv 2, 190007 (2019). doi: 10.29026/oea.2019.190007
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Review Open Access
Optofluidics: the interaction between light and flowing liquids in integrated devices
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Abstract
Optofluidics is a rising technology that combines microfluidics and optics. Its goal is to manipulate light and flowing liquids on the micro/nanoscale and exploiting their interaction in optofluidic chips. The fluid flow in the on-chip devices is reconfigurable, non-uniform and usually transports substances being analyzed, offering a new idea in the accurate manipulation of lights and biochemical samples. In this paper, we summarized the light modulation in heterogeneous media by unique fluid dynamic properties such as molecular diffusion, heat conduction, centrifugation effect, light-matter interaction and others. By understanding the novel phenomena due to the interaction of light and flowing liquids, quantities of tunable and reconfigurable optofluidic devices such as waveguides, lenses, and lasers are introduced. Those novel applications bring us firm conviction that optofluidics would provide better solutions to high-efficient and high-quality lab-on-chip systems in terms of biochemical analysis and environment monitoring.-
Keywords:
- optofluidics /
- optical devices /
- microfluidic chip
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References
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Zhu J M, Zhu X Q, Zuo Y F, Hu X J, Shi Y et al. Optofluidics: the interaction between light and flowing liquids in integrated devices. Opto-Electron Adv 2, 190007 (2019). doi: 10.29026/oea.2019.190007
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Figure 1.
The principle of optofluidic chip and two kinds of interaction between light and flowing liquids.
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Figure 2.
(a) The schematic of 3D liquid remodelability in a curved channel by centrifugal effect. (b) A 3D optofluidic dye laser. Figure reproduced from: (b) ref.15, The Royal Society of Chemistry.
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Figure 3.
(a) The schematic design of liquid GRIN lenses. (b) The GRIN lens by diffusion. (c) The GRIN lens by heat conduction. Figure reproduced from: (b) ref.32, The Royal Society of Chemistry; (c) ref.36, The Royal Society of Chemistry.
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Figure 4.
(a) (1) Light propagates in a straight way in homogeneous liquid medium. (2) Light bends in inhomogeneous liquid medium. (b) The schematic diagram and experimental images of optofluidic waveguide based on QCTO, which can focus light. (c) A QCTO optofluidic waveguide, bending light at 90°, 180°, and 270°. (d) A tunable liquid cloaking. Figure reproduced from: (b) ref.39, Macmillan Publishers Limited; (c) ref.40, Optical Society of America; (d) ref.41, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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Figure 5.
(a) The schematic of the on-chip flow cytometry, which is detected in two ways. One is detected by the traditional far-filed scattering light, and the other is detected by the near-field evanescent wave. (b) The Schematic diagram (1) and experimental images (2, 3) of a label-free bacteriophage detection by using droplet optofluidic imaging and far-field scattering light. (c) The design (1) and experimental image (2) of the single nanoparticle detection by total internal reflection. Figure reproduced from: (a) ref.51, Springer Nature; (b) ref.47, (c) ref.49, The Royal Society of Chemistry.
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Figure 6.
(a) Biomolecules detection based on optical force in sub-wavelength slot waveguides. (b) Cells sorting in an optical lattice. (c) Gold nanoparticles sorting in flowing system. (d) Multi-range particles sorting by quasi-Bessel beam. (e) Microparticles sorting based on optical lattice and chromatography. (f) Cell sorting by a new method combing acoustic force and optical force. Figure reproduced from: (a) ref.60, Macmillan Publishers Limited; (b) ref.58, Nature Publishing Group; (c) ref.61, American Chemical Society; (d) ref.62, The Royal Society of Chemistry; (e) ref.63; (f) ref.70, The Royal Society of Chemistry.
