Citation: | Song M, Ni X X, Wang L Q, et al. Saturation-to-hue mapping algorithm for improving the visibility of bleeding points under endoscopy[J]. Opto-Electron Eng, 2025, 52(3): 250007. doi: 10.12086/oee.2025.250007 |
[1] | Fakhr Abdollahi A, Shaheed M H, Thaha M A, et al. A review of modeling and control of remote-controlled capsule endoscopes[J]. Expert Rev Med Devices, 2024, 21(4): 293−306. doi: 10.1080/17434440.2024.2336135 |
[2] | Wu G X, Zhu R Z, Lu Y Q, et al. Optical scanning endoscope via a single multimode optical fiber[J]. Opto-Electron Sci, 2024, 3(3): 230041. doi: 10.29026/oes.2024.230041 |
[3] | Uchima H, Yao K S. Endoscopic microanatomy of the normal gastrointestinal mucosa with narrow band technology and magnification[J]. Gastroenterol Hepatol, 2019, 42(2): 117−126. doi: 10.1016/j.gastre.2019.02.006 |
[4] | Abraham E, Zhou J X, Liu Z W. Speckle structured illumination endoscopy with enhanced resolution at wide field of view and depth of field[J]. Opto-Electron Adv, 2023, 6(7): 220163. doi: 10.29026/oea.2023.220163 |
[5] | 王双园, 姚志远, 张玉荣, 等. 一种多层线性融合的内窥镜图像增强算法[J]. 光电工程, 2024, 51(6): 240063. doi: 10.12086/oee.2024.240063 Wang S Y, Yao Z Y, Zhang Y R, et al. A multilayer linear fusion algorithm for endoscopic image enhancement[J]. Opto-Electron Eng, 2024, 51(6): 240063. doi: 10.12086/oee.2024.240063 |
[6] | Utsunomiya H, Akazawa Y, Ueyama H, et al. Gastric juvenile polyposis with intramucosal cancer diagnosed by magnifying endoscopy with narrow-band imaging[J]. Intern Med, 2023, 62(22): 3333−3339. doi: 10.2169/internalmedicine.1612-23 |
[7] | 姜鸿鹏, 章科建, 袁波, 等. 一种血管内窥镜图像增强算法[J]. 光电工程, 2019, 46(1): 180167. doi: 10.12086/oee.2019.180167 Jiang H P, Zhang K J, Yuan B, et al. A vascular enhancement algorithm for endoscope image[J]. Opto-Electron Eng, 2019, 46(1): 180167. doi: 10.12086/oee.2019.180167 |
[8] | 王强, 陶沛, 袁波, 等. 多颜色空间的内窥镜图像血管增强方法[J]. 光电工程, 2020, 47(1): 190268. doi: 10.12086/oee.2020.190268 Wang Q, Tao P, Yuan B, et al. Vessel enhancement of endoscopic image based on multi-color space[J]. Opto-Electron Eng, 2020, 47(1): 190268. doi: 10.12086/oee.2020.190268 |
[9] | Moskalev A, Kalyagina N, Kozlikina E, et al. Validation of a white light and fluorescence augmented panoramic endoscopic imaging system on a bimodal bladder wall experimental model[J]. Photonics, 2024, 11(6): 514. doi: 10.3390/photonics11060514 |
[10] | Yang C H, Qiu Y, Li X, et al. Bleeding after endoscopic submucosal dissection of gastric lesions[J]. J Dig Dis, 2020, 21(3): 139−146. doi: 10.1111/1751-2980.12850 |
[11] | Funasaka K, Miyahara R, Horiguchi N, et al. Novel image enhancement technology that helps find bleeding points during endoscopic submucosal dissection of gastric neoplasms[J]. J Gastroenterol Hepatol, 2022, 37(10): 1955−1962. doi: 10.1111/jgh.15975 |
[12] | Oka K, Iwai N, Okuda T, et al. Red dichromatic imaging improves visibility of bleeding during gastric endoscopic submucosal dissection[J]. Sci Rep, 2023, 13(1): 8560. doi: 10.1038/s41598-023-35564-z |
[13] | Furuichi Y, Abe M, Takeuchi H, et al. Red dichromatic imaging reduces endoscopic treatment time of esophageal varices by increasing bleeding point visibility (with video)[J]. Dig Endosc, 2022, 34(1): 87−95. doi: 10.1111/den.14011 |
[14] | Takahashi J, Hirota M, Morita Y. Endoscope apparatus, operating method of endoscope apparatus, and information storage medium: 20210401268[P]. 2021-12-30. |
[15] | Smucker M D, Allan J, Carterette B. Agreement among statistical significance tests for information retrieval evaluation at varying sample sizes[C]//Proceedings of the 32nd international ACM SIGIR Conference on Research and Development in Information Retrieval, Boston, 2009: 630–631. https://doi.org/10.1145/1571941.1572050. |
[16] | Mokrzycki W S, Tatol M. Colour difference ΔE - a survey[J]. Mach Graph Vis Int J, 2011, 20(4): 383−411. |
Bleeding frequently occurs during endoscopic procedures for diagnosis and surgery. The presence of blood can obstruct the endoscopic field of view, causing difficulty in detecting bleeding points. Excessive or frequent coagulation may lead to carbonation in the submucosal layer, which increases surgical difficulty and risk. Therefore, enhancing the visibility of the surgical field, and increasing the color difference between bleeding points and surroundings are clinically significant. To address the issue of poor visibility of submerged bleeding points during endoscopic surgery, a method combining 4-LED illumination with a saturation-to-hue mapping algorithm is proposed for enhancing bleeding points' visibility.
Based on imaging theory through multilayer tissue, four narrowband LEDs (450 nm, 520 nm, 590 nm, 650 nm) with specificity for imaging tissues and different concentrations of blood are used for synchronous illumination, replacing traditional xenon lamp light sources for imaging. This can capture more information about bleeding points through low-concentration blood. Then, in the xyY color space, the saturation information of the color image is stretched and mapped to hue. Combined with image brightness and contrast adjustment, the low-concentration blood areas are mapped to cyan-yellow, and the high-concentration bleeding points as orange-red, effectively improving the color difference between the submerged bleeding point and the surroundings. The need for specialized video camera systems or RDIver circuits for the light source is eliminated, and the issues of color fringing and image misalignment associated with separate narrowband illumination are avoided.
The sample set is derived from in vitro experiments conducted with phantoms crafted from animal materials. Regarding the experimental equipment, rigid endoscopes are used for in vitro experimentation, and the complementary apparatus includes a 4K endoscope camera system and a 5-LED medical endoscope cold light source. After enhancing the phantom images, the color difference between the bleeding points and their surrounding areas is significantly higher than that in conventional white light images (41.31 > 11.78). Paired Student's t-test was conducted to compare the enhanced images with the white light images, and the statistical significance score is less than 0.01. This effectively improves the visibility of submerged bleeding points, further reducing the risks associated with endoscopic surgeries.
Diagram of image enhancement method
Schematic of light intensity attenuation. (a) Submerged bleeding point; (b) The area around bleeding point
Spectrum of the 4LED combined light
Flowchart of the saturation-to-hue mapping algorithm
Color change in the original and enhanced image
Schematic and actual views of the experimental setup. (a) Schematic of experimental setup; (b) Actual structure of the endoscope and phantom; (c) Experimental system diagram including the video camera system, light source, display, endoscope, and phantom
Different conditions of the blood point phantom. (a) White light imaging (WLI); (b) SHMI; (c) RDI
CIE-L·a·b color space expressed on three-dimensional geometry with the bleeding point and blood pool plotted. (a) The color coordinates of subgraph 1 in Fig. 7; (b) The color coordinates of subgraph 2 in Fig. 7